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Animal models

Metabolic animal models :


  • Hypercholesterolemic Mouse Model: LDLr KO, ApoE KO,




  • Metabolic Syndrome Model: Mouse under high fat diet (obesity) or fructose / diet deficient diet choline (steatosis)



  • Bariatric Surgery Mouse Model: Sleeve Gastrectomy and

Y Gastric Bypass




Vascular animal models :


  • Arterial hypertension (L-NAME, Angiotensin II, renal artery stenosis)

Animal model: rat, mice

These models are characterized by the inhibition of endothelial NO synthase after LNAME administration in drinking

water or increase the plasma concentration of angiotensin II (AII) (stenosis of renal artery or implantation of osmotic minipompe of IIA). These models can be studied between 2-4 weeks.


  • Pulmonary Arterial Hypertension

Animal model: rat, mice

Model induced by hypoxia during 2-5 weeks (Hypoxic chamber).





Cardiac animal models :


  • Septic shock

Animal model: rat

Method: intravenous injection of lipopolysaccharide of Escherichia coli. This model can be studied between 3 pm – 24 hours post-injection.


  • Ischemic heart failure

Animal model: rat

Method: left coronary artery ligature with a study during the acute phase of myocardial infarction or later, up to 12 weeks post-ligature, with 2 levels of heart failure, compensated and decompensated.


  • Progressive cardiac conduction disease

Animal model: heterozygous knock-out mice for the gene Scn5a which code the sodium channel Nav1.5.


  • Dilated cardiomyopathy

Animal model: rat

induced by chronic treatment with Adriamycin




Pulmonary animal models:


  • Acute asthma models: study of asthma exacerbations (ovalbumine or house dust mite extract)

It takes about 4 weeks (depending on protocol) and allows the generation of effectors T cells in asthma (no clinical symptom appears during this phase). This leads to the generation of inflammation when animals receive antigen exposure directly to the lungs via nasal instillation.


  • Chronic asthma models for the study of airway remodeling in asthma (ovalbumine or house dust mite extract)

These protocols take about 16 weeks (depending on protocol) and do not lead to any clinical symptoms. Mice are sensitized the first 3 weeks with allergen. Then during the following weeks, mice are regularly anesthetized to receive antigen exposure directly to the lungs via nasal instillation.




Digestive animal models :


  • Disorder of the digestive motricity (adult and newborn)

atresia of the hail; SRF – SM – create (T2)


  • Intestinal inflammatory diseases (rats, mice)

TNBS (chemo-induced colitis), IL10-/- (enterocolitis mimicking Crohn’s disease)


  • Neurodegenerative diseases (mouse, rat)

Rat Tg α-synuclein human, mouse rotenone…






  • Sub-cutaneous xenograft mouse models

  • Disseminated mouse models in development