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Dilasser F, Rose L, Hassoun D, Klein M, Rousselle M, Brosseau C, Guignabert C, Taillé C, Dombret MC, Di Candia L, Heddebaut N, Bouchaud G, Pretolani M, Magnan A, Loirand G, Sauzeau V. Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling. Thorax. 2021 Feb 4.


Dhot J, Prat V, Ferron M, Aillerie V, Erraud A, Rozec B, Waard M, Gauthier C, Lauzier B. Implications of a Soy-Based Diet for Animal Models. Int J Mol Sci. 2021 Jan 14;22(2):774.


Klein M, Colas L, Cheminant MA, Brosseau C, Sauzeau V, Magnan A, Bouchaud G. Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization. Front Immunol. 2020 11:565431


Margier M, Le May C, Antoine T, Halimi C, Nowicki M, Lespine A, Reboul E. P-glycoprotein (ABCB1) is involved in vitamin K efflux Food Chem 2020 Nov 1;128510


Dupas T, Denis M, Dontaine J, Persello A, Bultot L, Erraud A, Vertommen D, Bouchard B, Tessier A, Rivière M, Lebreton J, Bigot-Corbel E, Montnach J, De Waard M, Gauthier C, Burelle Y, Olson AK, Rozec B, Des Rosiers C, Bertrand L, Issad T, Lauzier B. Protein O-GlcNAcylation levels are regulated independently of dietary intake in a tissue and time-specific manner during rat postnatal development. Acta Physiol (Oxf). 2020 Oct 6:e13566.


Lafoux A, Lotteau S, Huchet C, Ducreux S. The contractile phenotype of skeletal muscle in TRPV1 knockout mice is gender specific and exercise-dependent. Life 2020 Oct 10,233


Caudal D, François V, Lafoux A, Ledevin M, Anegon I, Le Guiner C, Larcher T, Huchet C. Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model. PLoS One. 2020 Mar 11;15(3)


Seiller C, Maiga S, Touzeau C, Bellanger C, Kervoëlen C, Descamps G, Maillet L, Moreau P, Pellat-Deceunynck C, Gomez-Bougie P, Amiot M. Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes. Cell Death Dis. 2020 May 5;11(5):316


Moui A, Klein M, Hassoun D, Dijoux E, Cheminant MA, Magnan A, Bouchaud G. The IL-15/sIL-15Rα complex modulates immunity without effect on asthma features in mouse. Respir Res. 2020 Jan 29;21(1):33





Ferron M, Cadiet J, Persello A, Prat V, Denis M, Erraud A, Aillerie V, Mevel M, Bigot E, Chatham JC, Gauthier C, Rozec B, Lauzier B. O-GlcNAc stimulation: A new metabolic approach to treat septic shock. Sci Rep. 2019 Dec 10;9(1):18751


Ouisse LH, Remy S, Lafoux A, Larcher T, Tesson L, Chenouard V, Guillonneau C, Brusselle L, Vimond N, Rouger K, Péréon Y, Chenouard A, Gras-Le Guen C, Braudeau C, Josien R, Huchet C, Anegon I. Immunophenotype of a Rat Model of Duchenne’s Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment. Front Immunol. 2019 Sep 9;10:2131

Aubert P, Guinobert I, Blondeau C, Bardot V, Ripoche I, Chalard P, Neunlist M. Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study. J Med Food. 2019 Jul;22(7):653-662.


Coué M, Tesse A, Falewée J, Aguesse A, Croyal M, Fizanne L, Chaigneau J, Boursier J, Ouguerram K. Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid. Nutrients. 2019 Jan 18;11(1)





Regnault C, Usal M, Veyrenc S, Couturier K, Batandier C, Bulteau AL, Lejon D, Sapin A, Combourieu B, Chetiveaux M, Le May C, Lafond T, Raveton M, Reynaud S. Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4416-E4425.


André-Grégoire G, Dilasser F, Chesné J, Braza F, Magnan A, Loirand G, Sauzeau V. Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness. J Allergy Clin Immunol. 2018 Sep;142(3):824-833.

Castan L, Cheminant MA, Colas L, Brouard S, Magnan A, Bouchaud G. Food allergen-sensitized CCR9+ lymphocytes enhance airways allergic inflammation in mice. Allergy. 2018 Jul;73(7):1505-1514.

Dumontet C, Beck G, Gardebien F, Haudecoeur R, Mathé D, Matera EL, Tourette A, Mattei E, Esmenjaud J, Boyère C, Nurisso A, Peuchmaur M, Pérès B, Bouchaud G, Magnan A, Monneret G, Boumendjel A. Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models. Eur J Med Chem. 2018 Oct 5;158:405-413. 






Caudal D, Guinobert I, Lafoux A, Bardot V, Cotte C, Ripoche I, Chalard P, Huchet C.  Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. J Tradit Complement Med. 2017 Oct 12;8(2):335-340.


Carbone ML, Chadeuf G, Heurtebise-Chrétien S, Prieur X, Quillard T, Goueffic Y, Vaillant N, Rio M, Castan L, Durand M, Baron-Menguy C, Aureille J, Desfrançois J, Tesse A, Torres RM, Loirand G. Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis. J Clin Invest. 2017 127(12):4516-4526.

Derangeon M, Montnach J, Cerpa CO, Jagu B, Patin J, Toumaniantz G, Girardeau A, Huang CLH, Colledge WH, Grace AA, Baró I, Charpentier F. Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease. Cardiovasc Res. 2017 – 113(5):464-474. 


Harford-Wright E, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver L, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017 Nov 1;140(11):2939-2954.





Lafoux A, Baudry C, Bonhomme C, Le Ruyet P, Huchet C. Soluble Milk Protein Supplementation with Moderate Physical Activity Improves Locomotion Function in Aging Rats. PLoS One. 2016 Dec 14;11(12):e0167707


Portero V, Le Scouarnec S, Es-Salah-Lamoureux Z, Burel S, Gourraud JB, Bonnaud S, Lindenbaum P, Simonet F, Violleau J, Baron E, Moreau E, Scott C, Chatel S, Loussouarn G, O’Hara T, Mabo P, Dina C, Le Marec H, Schott JJ, Probst V, Baró I, Marionneau C, Charpentier F, Redon R. Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome. J Am Heart Assoc. 2016 Jun 10;5(6) .


Brégeon J., Coron E., Da Silva AC., Jaulin J., Aubert P., Chevalier J., Vergnolle N., Meurette G., Neunlist M. Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model. J Physiol. 2016 594(15):4309-23.


Randriamboavonjy J, Loirand G, Vaillant N, Lauzier B, Derbré S, Michalet S, Pacaud P, Tesse A. Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats. Am J Hypertens. 2016 Jul;29(7):873-81.





Rocheteau P, Chatre L, Briand D, Mekarki M, Jouvion G, Bardon J, Crochemore C, Serrani P, Lecci PP, Latil M, Matot B, Carlier PG, Latronico N, Huchet C, Lafoux A, Sharshar T, Ricchetti M, Chretien F. Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy. Nat. Commun. 2015 Dec 15;6:10145.


Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M. Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with Crohn’s disease. Gastroenterology 2015 Nov 11. pii: S0016-5085(15)01394-3. 


Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baro I, Zibara K, Lemarchand P, Gaborit N. Toward personalized medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome. J Am Heart Assoc. 2015;4:e002159. 


Bouchaud G, Gourbeyre P, Bihouée T, Aubert P , Lair D, Cheminant MA, Denery-Papini S, Neunlist M, Magnan A and Bodinier M. Consecutive food and respiratory allergies amplify systemic and gut but not lung outcomes in mice.  Agric. Food Chem. 2015, 63, 6475−83.


Berger JM, Vauillant N, Le May C, Calderon C, Brégeon J, Prieur X, Hadchouel J, Loirand G, Cariou B. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis. 2015 Mar;239(1):252-9. 


Chesné J, Braza F, Chadeuf G, Mahay G, Cheminant MA, Loy J, Brouard S, Sauzeau V, Loirand G, Magnan A. Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model. J Allergy Clin Immunol. 2015 ;135(6):1643-1643.e3.




Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Concordet JP, Anegon I, Huchet C. Characterization of dystrophin deficient rats: a new model for duchenne muscular dystrophy. PLoS One. 2014 13;9(10):e110371


Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response. J Exp Med. 2014;211(9):1779-92

Bihouée T, Bouchard G, Chesné J, Lair D, Rolland-Debord C, Braza F, Cheminant MA, Aubert P, Mahay G, Sagan C, Neunlist M, Brouard S, Bodinier M, Magnan A. Food allergy enhances allergic asthma in mice.  Respir Res. 2014 Nov 30;15(1):142





Tasselli M, Chaumette T, Paillusson S, Monnet Y, Lafoux A, Huchet-Cadiou C, Aubert P, Hunot S, Derkinderen P, Neunlist M. Effects of oral administration of rotenone on gastrointestinal functions in mice. Neurogastroenterol Motil. 2013; 25(3):e183-93.


Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Saati TA, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. J Hepatol. 2013; 58(5):984-92.


Rakotomalala G, Agard C, Tonnerre P, Tesse A, Derbré S, Michalet S, Hamzaoui J, Rio M, Cario-Toumaniantz C, Richomme P, Charreau B, Loirand G, Pacaud P. Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension. J Ethnopharmacol. 2013; 148(1):106-16.

Chantôme A, Potier-Cartereau M, Clarysse L, Fromont G, Marionneau-Lambot S, Guéguinou M, Pagès JC, Collin C, Oullier T, Girault A, Arbion F, Haelters JP, Jaffrès PA, Pinault M, Besson P, Joulin V, Bougnoux P, Vandier C. Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases.  Cancer Res. 2013; 73(15):4852-61.

Potiron V, Abderrahmani R, Clément-Colmou K, Marionneau-Lambot S, Oullier T, Paris F, Supiot S. Improved functionality of the vasculature during conventionally fractionated radiation therapy of prostate cancer. PLoS One. 2013; 8(12):e84076.





Vinet L, Pezet M, Bito V, Briec F, Biesmans L, Rouet-Benzineb P, Gellen B, Prévilon M, Chimenti S, Vilaine JP, Charpentier F, Sipido KR, Mercadier JJ. Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts. Basic Res. Cardiol. 2012; 107(2): 1-14.





Pre-clinical study of 21 approved drugs in the mdx mouse. Carre-Pierrat M, Lafoux A, Tanniou G, Chambonnier L, Divet A, Fougerousse F, Huchet-Cadiou C, Ségalat L. Neuromuscul Disord. 2011;21(5):313-27.


Leroy J, Richter W, Mika D, Castro LR, Abi-Gerges A, Xie M, Scheitrum C, Lefebvre F, Schittl J, Mateo P, Westenbroek R, Catterall WA, Charpentier F, Conti M, Fischmeister R, Vandecasteele G. Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice. J. Clin. Invest. 2011; 121(7): 2651-61.


Bignolais O, Quang KL, Naud P, El Harchi A, Briec F, Piron J, Bourgé A, Leoni AL, Charpentier F, Demolombe S. Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block. J. Mol. Cell. Cardiol. 2011; 51(5): 713-21.


Gayard M, Guilluy C, Rousselle A, Viollet B, Henrion D, Pacaud P, Loirand G, Rolli-Derkinderen M. AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol. Arterioscler Thromb Vasc Biol. 2011; 31(11): 2634-42.


Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J. WNK1 regulates vasoconstriction and blood pressure response to 1-adrenergic stimulation in mice. Hypertension, 2011 58(3):439-45.





Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E,  Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010; 16(2): 183-90.


Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge CH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F. Variable Nav1.5 protein expression from the wild-type allele correlates with phenotypic penetrance in the Scn5a+/- mouse model for cardiac conduction disease. PLoS ONE 2010; 19.5: e9298.


Renault MA, Robbesyn F, Réant P, Douin V, Daret D, Allières C, Belloc I, Couffinhal T, Arnal JF, Klingel K, Desgranges C, Dos Santos P, Charpentier F, Gadeau AP. Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy. Circ Heart Fail. 2010; 3: 431-39.


Djata Cabral M, Paulet PE, Robert V, Gomes B, Renoud ML, Savignac M, Leclerc C, Moreau M, Lair D, Langelot M, Magnan A, Yssel H, Mariame B, Guery JC, Pelletier L. Knocking-down Cav1 Calcium Channels Implicated in Th2-cell Activation Prevents Experimental Asthma. Am J Respir Crit Care Med. 2010;181(12):1310-7.


Mionnet C, Buatois V, Kanda A, Milcent V, Fleury S, Lair D, Langelot M. Lacoeuille Y, Hessel E, Coffman R, Magnan A, Dombrowicz DD, Glaichenhaus N, Julia V. CX3CR1 is required for allergic airway inflammation by promoting Th2 cell survival and maintenance in inflamed lung. Nat Med. 2010;16(11):1305-12.