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Publications

2018

 

Regnault C, Usal M, Veyrenc S, Couturier K, Batandier C, Bulteau AL, Lejon D, Sapin A, Combourieu B, Chetiveaux M, Le May C, Lafond T, Raveton M, Reynaud S. Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4416-E4425

 

 

2017

 

Carbone ML, Chadeuf G, Heurtebise-Chrétien S, Prieur X, Quillard T, Goueffic Y, Vaillant N, Rio M, Castan L, Durand M, Baron-Menguy C, Aureille J, Desfrançois J, Tesse A, Torres RM, Loirand G. Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis. J Clin Invest. 2017 Nov 13.

 

André-Grégoire G, Dilasser F, Chesné J, Braza F, Magnan A, Loirand G, Sauzeau V. Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness. J Allergy Clin Immuno. 2017 Nov 16.

 

Derangeon M, Montnach J, Cerpa CO, Jagu B, Patin J, Toumaniantz G, Girardeau A, Huang CLH, Colledge WH, Grace AA, Baró I, Charpentier F. Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease. Cardiovasc Res. 2017 – 113(5):464-474.

 

 

2016

 

 

Lafoux A, Baudry C, Bonhomme C, Le Ruyet P, Huchet C. Soluble Milk Protein Supplementation with Moderate Physical Activity Improves Locomotion Function in Aging Rats. PLoS One. 2016 Dec 14;11(12):e0167707

 

Portero V, Le Scouarnec S, Es-Salah-Lamoureux Z, Burel S, Gourraud JB, Bonnaud S, Lindenbaum P, Simonet F, Violleau J, Baron E, Moreau E, Scott C, Chatel S, Loussouarn G, O’Hara T, Mabo P, Dina C, Le Marec H, Schott JJ, Probst V, Baró I, Marionneau C, Charpentier F, Redon R. Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome. J Am Heart Assoc. 2016 Jun 10;5(6) .

 

Brégeon J., Coron E., Da Silva AC., Jaulin J., Aubert P., Chevalier J., Vergnolle N., Meurette G., Neunlist M. Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model. J Physiol. 2016 594(15):4309-23.

 

Randriamboavonjy J, Loirand G, Vaillant N, Lauzier B, Derbré S, Michalet S, Pacaud P, Tesse A. Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats. Am J Hypertens. 2016 Jul;29(7):873-81.

 

 

2015

 

Rocheteau P, Chatre L, Briand D, Mekarki M, Jouvion G, Bardon J, Crochemore C, Serrani P, Lecci PP, Latil M, Matot B, Carlier PG, Latronico N, Huchet C, Lafoux A, Sharshar T, Ricchetti M, Chretien F. Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy. Nat. Commun. 2015 Dec 15;6:10145.

 

Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M. Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with Crohn’s disease. Gastroenterology 2015 Sep 30. pii: S0016-5085(15)01394-3. 

 

Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baro I, Zibara K, Lemarchand P, Gaborit N. Toward personalized medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome. J Am Heart Assoc. 2015;4:e002159. 

 

Bouchaud G, Gourbeyre P, Bihouée T, Aubert P , Lair D, Cheminant MA, Denery-Papini S, Neunlist M, Magnan A and Bodinier M. Consecutive food and respiratory allergies amplify systemic and gut but not lung outcomes in mice.  Agric. Food Chem. 2015, 63, 6475−83.

 

Berger JM, Vauillant N, Le May C, Calderon C, Brégeon J, Prieur X, Hadchouel J, Loirand G, Cariou B. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis. 2015 Mar;239(1):252-9. 

 

Chesné J, Braza F, Chadeuf G, Mahay G, Cheminant MA, Loy J, Brouard S, Sauzeau V, Loirand G, Magnan A. Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model. J Allergy Clin Immunol. 2015 ;135(6):1643-1643.e3.

 

 

2014

 

Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Concordet JP, Anegon I, Huchet C. Characterization of dystrophin deficient rats: a new model for duchenne muscular dystrophy. PLoS One. 2014 13;9(10):e110371

 

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response. Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. J Exp Med. 2014;211(9):1779-92


Food allergy enhances allergic asthma in mice. Bihouée T, Bouchard G, Chesné J, Lair D, Rolland-Debord C, Braza F, Cheminant MA, Aubert P, Mahay G, Sagan C, Neunlist M, Brouard S, Bodinier M, Magnan A. Respir Res. 2014 Nov 30;15(1):142


 

2013

 

Effects of oral administration of rotenone on gastrointestinal functions in mice. Tasselli M, Chaumette T, Paillusson S, Monnet Y, Lafoux A, Huchet-Cadiou C, Aubert P, Hunot S, Derkinderen P, Neunlist M. Neurogastroenterol Motil. 2013; 25(3):e183-93.

 

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Saati TA, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. J Hepatol. 2013; 58(5):984-92.

 

Rakotomalala G, Agard C, Tonnerre P, Tesse A, Derbré S, Michalet S, Hamzaoui J, Rio M, Cario-Toumaniantz C, Richomme P, Charreau B, Loirand G, Pacaud P. Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension. J Ethnopharmacol. 2013; 148(1):106-16.

 

Chantôme A, Potier-Cartereau M, Clarysse L, Fromont G, Marionneau-Lambot S, Guéguinou M, Pagès JC, Collin C, Oullier T, Girault A, Arbion F, Haelters JP, Jaffrès PA, Pinault M, Besson P, Joulin V, Bougnoux P, Vandier C. Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases. Cancer Res. 2013; 73(15):4852-61.

 

Potiron V, Abderrahmani R, Clément-Colmou K, Marionneau-Lambot S, Oullier T, Paris F, Supiot S. Improved functionality of the vasculature during conventionally fractionated radiation therapy of prostate cancer. PLoS One 2013; 8(12):e84076.

 

 

2012

 

Vinet L, Pezet M, Bito V, Briec F, Biesmans L, Rouet-Benzineb P, Gellen B, Prévilon M, Chimenti S, Vilaine JP, Charpentier F, Sipido KR, Mercadier JJ. Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts. Basic Res. Cardiol. 2012; 107(2): 1-14.

 

 

2011

 

Pre-clinical study of 21 approved drugs in the mdx mouse. Carre-Pierrat M, Lafoux A, Tanniou G, Chambonnier L, Divet A, Fougerousse F, Huchet-Cadiou C, Ségalat L. Neuromuscul Disord. 2011;21(5):313-27.

 

 

Bignolais O, Quang KL, Naud P, El Harchi A, Briec F, Piron J, Bourgé A, Leoni AL, Charpentier F, Demolombe S. Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block. J. Mol. Cell. Cardiol. 2011; 51(5): 713-21.

 

Gayard M, Guilluy C, Rousselle A, Viollet B, Henrion D, Pacaud P, Loirand G, Rolli-Derkinderen M. AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol. Arterioscler Thromb Vasc Biol. 2011; 31(11): 2634-42.

 

Bergaya S, Faure S, Baudrie V, Rio M, Escoubet B, Bonnin P, Henrion D, Loirand G, Achard JM, Jeunemaitre X, Hadchouel J. WNK1 regulates vasoconstriction and blood pressure response to 1-adrenergic stimulation in mice. Hypertension, 2011 58(3):439-45.

 

 

2010

 

Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E,  Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010; 16(2): 183-90.

 

Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge CH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F. Variable Nav1.5 protein expression from the wild-type allele correlates with phenotypic penetrance in the Scn5a+/- mouse model for cardiac conduction disease. PLoS ONE 2010; 19.5: e9298.

 

Renault MA, Robbesyn F, Réant P, Douin V, Daret D, Allières C, Belloc I, Couffinhal T, Arnal JF, Klingel K, Desgranges C, Dos Santos P, Charpentier F, Gadeau AP. Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy. Circ Heart Fail. 2010; 3: 431-39.

 

Djata Cabral M, Paulet PE, Robert V, Gomes B, Renoud ML, Savignac M, Leclerc C, Moreau M, Lair D, Langelot M, Magnan A, Yssel H, Mariame B, Guery JC, Pelletier L. Knocking-down Cav1 Calcium Channels Implicated in Th2-cell Activation Prevents Experimental Asthma. Am J Respir Crit Care Med. 2010;181(12):1310-7.

 

Mionnet C, Buatois V, Kanda A, Milcent V, Fleury S, Lair D, Langelot M. Lacoeuille Y, Hessel E, Coffman R, Magnan A, Dombrowicz DD, Glaichenhaus N, Julia V. CX3CR1 is required for allergic airway inflammation by promoting Th2 cell survival and maintenance in inflamed lung. Nat Med. 2010;16(11):1305-12.

 

 

2009

 

Biliczki P, Girmatsion Z, Brandes RP, Harenkamp S, Pitard B, Charpentier F, Hébert TE, Hohnloser SH, Baró I, Nattel S, Ehrlich JR. Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization. Heart Rhythm 2009; 6(12):1792-801.

 

Chaumette T, Lebouvier T, Aubert P, Lardeux B, Qin C, Li Q, Accary D, Bézard E, Bruley des Varannes S, Derkinderen P, Neunlist M. Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism. Neurogastroenterol Motil. 2009 21(2):215-22.

 

Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut. 2009 58(2):196-201.

 

Agard C, Rolli-Derkinderen M, Dumas-de-La-Roque E, Rio M, Sagan C, Savineau JP, Loirand G, Pacaud P. Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. Br. J. Pharmacol. 2009, 158(5):1285-94.

 

Audigane L, Kerfant BG, El Harchi A, Lorenzen-Schmidt I, Toumaniantz G, Cantereau A, Potreau D, Charpentier F, Noireaud J, Gauthier C. Rabbit, a relevant model for the study of cardiac beta 3-adrenoceptors. Exp. Physiol. 2009; 94: 400-11.

 

Fernandes S, van Rijen HV, Forest V, Evain S, Leblond AL, Mérot J, Charpentier F, de Bakker JM, Lemarchand P. Cardiac Cell Therapy: Overexpression of Connexin43 in Skeletal Myoblasts and Prevention of Ventricular Arrhythmias. J. Cell. Mol. Med. 2009 13(9B):3703-12

 

Langhi C, May CL, Gmyr V, Vandewalle B, Kerr-Conte J, Krempf M, Pattou F, Costet P, Cariou B. PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion. Biochem Biophys Res Commun. 2009 25;390(4):1288-93

 

Le May C, Kourimate S, Langhi C, Chétiveaux M, Jarry A, Comera C, Collet X, Kuipers F, Krempf M, Cariou B, Costet P. Proprotein Convertase Subtilisin Kexin  Type 9 null mice are protected fromm postprandial triglyceridemia. Arterioscler Thromb Vasc Biol. 2009 29(5):684-90.

 

Tran Quang T, Rozec B, Audigane L, Gauthier C. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta. Br J Pharmacol. 2009 156(4):601-8.

Rozec B, Erfanian M, Laurent K, Trochu JN, Gauthier C. Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart. J Am Coll Cardiol. 2009 53(17):1532-38.

 

Yoshiki H, Nishimune A, Suzuki F, Morishima S, Ikeda T, Sasaki M, Audigane L, Gauthier C, Muramatsu I. Evaluation of ß1L-adrenoceptors in rabbit heart by tissue segment binding assay. Journal of Pharmacological Sciences, 2009, 110(3):389-96.

 

 

2008

 

Charpentier F, Bourgé A, Mérot J. Mouse models of SCN5A-related cardiac arrhythmias. Prog. Biophys. Mol. Biol. 2008 98(2-3):230-7.

 

Chevalier J, Derkinderen P, Gomes P, Thinard R, Naveilhan P, Vanden Berghe P, Neunlist M. Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system. J Physiol. 2008 Apr 1;586(7):1963-75.

 

Gellen B, Fernández-Velasco M, Briec F, Vinet L, LeQuang K, Rouet-Benzineb P, Bénitah JP, Pezet M, Palais G, Pellegrin N, Zhang A, Perrier R, Escoubet B, Marniquet X, Richard S, Jaisser F, Gómez AM, Charpentier F, Mercadier JJ. Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation 2008;117(14):1778-86.

 

Guilluy C, Rolli-Derkinderen M, Loufrani L, Bourgé A, Henrion D, Sabourin L, Loirand G, Pacaud P. Ste20-Related Kinase SLK Phosphorylates Ser188 of RhoA to Induce Vasodilation in Response to Angiotensin II Type 2 Receptor Activation. Circ Res. 2008;102(10):1265-74.

 

Kourimate S., Le May C., Langhi C., Jarnoux AL., Ouguerram K., Zaïr Y., Nguyen P., Krempf M., Cariou B., and Costet P.. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. J. Biol. Chem. 2008 Apr 11;283(15):9666-73.

 

Langhi C., Le May C., Kourimate S., Caron S., Staels B., Krempf M., Costet P., Cariou B.. Activation of the farnesoid X receptor represses pcsk9 expression in human hepatocytes. FEBS Lett. 2008 Mar 19;582(6):949-55.

 

Lebouvier T, Chaumette T, Damier P, Coron E, Touchefeu Y, Vrignaud S, Naveilhan P, Galmiche JP, Bruley des Varannes S, Derkinderen P, Neunlist M. Pathological lesions in colonic biopsies during Parkinson’s disease. Gut. 2008 Dec;57(12):1741-3.

 

Loirand G, Rolli-Derkinderen M, Pacaud P. Urotensin II and atherosclerosis. Peptides.2008 May;29(5):778-82.

 

Loirand G, Scalbert E, Bril A, Pacaud P. Rho exchange factors in the cardiovascular system. Curr Opin Pharmacol. 2008, 8(2):174-80.

 

Neunlist M, Van Landeghem L, Bourreille A, Savidge T. Neuro-glial crosstalk in inflammatory bowel disease. J Intern Med. 2008 Jun;263(6):577-83.

 

Piron J, Quang KL, Briec F, Amirault JC, Leoni AL, Desigaux L, Escande D, Pitard B, Charpentier F. Biological Pacemaker Engineered by Nonviral Gene Transfer in a Mouse Model of Complete Atrioventricular Block. Mol. Ther. 2008;16(12):1937-43.

 

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor.

Effects of oral administration of rotenone on gastrointestinal functions in mice.